Demetrios T Braddock Selected Research

Arterial calcification of infancy

1/2022	Catalysis-Independent ENPP1 Protein Signaling Regulates Mammalian Bone Mass.
1/2021	Improving the Pharmacodynamics and In Vivo Activity of ENPP1-Fc Through Protein and Glycosylation Engineering.
1/2021	Genetic pathways disrupted by ENPP1 deficiency provide insight into mechanisms of osteoporosis, osteomalacia, and paradoxical mineralization.
12/2015	ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy.

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Demetrios T Braddock Research Topics

Disease

6	Neoplasms (Cancer) 01/2022 - 07/2008
5	Osteoporosis 01/2022 - 01/2020
5	Hypophosphatemic Rickets 01/2022 - 01/2021
4	Arterial calcification of infancy 01/2022 - 12/2015
3	Rickets (Rachitis) 01/2022 - 01/2021
2	Vascular Calcification 01/2022 - 12/2015
2	Enthesopathy 01/2022 - 01/2020
2	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/2022 - 01/2022
2	Osteomalacia 01/2022 - 01/2022
2	Metabolic Bone Diseases (Osteopenia) 01/2022 - 01/2021
2	Nephrocalcinosis 01/2021 - 01/2017
2	Neoplasm Metastasis (Metastasis) 08/2011 - 06/2010
1	Heart Injuries 01/2022
1	Pain (Aches) 01/2022
1	Renal Insufficiency (Renal Failure) 01/2021
1	Primary Hyperparathyroidism 01/2020
1	Reticulocytosis 10/2016
1	Splenomegaly 10/2016
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2016
1	Sclerosis 12/2015
1	Lymphoma (Lymphomas) 02/2015
1	Type 2 Diabetes Mellitus (MODY) 06/2014
1	Weight Gain 06/2014
1	Stroke (Strokes) 02/2014
1	Vascular System Injuries 11/2012
1	Multiple Sclerosis 08/2011
1	Nevus (Nevi) 10/2008
1	Melanoma (Melanoma, Malignant) 10/2008

Drug/Important Bio-Agent (IBA)

5	EnzymesIBA 01/2022 - 10/2008
4	Phosphates (Orthophosphate)IBA 01/2022 - 01/2017
3	Fibroblast Growth Factor-23IBA 01/2022 - 01/2022
3	ectonucleotide pyrophosphatase phosphodiesterase 1IBA 01/2022 - 01/2021
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2008
3	diphosphoric acid (pyrophosphoric acid)IBA 01/2021 - 12/2015
3	MineralsIBA 01/2020 - 01/2017
3	lysophosphatidic acidIBA 08/2011 - 10/2008
2	PyrophosphatasesIBA 01/2021 - 02/2014
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2021 - 02/2014
2	MicroRNAs (MicroRNA)IBA 11/2020 - 02/2015
2	Pharmaceutical PreparationsIBA 02/2015 - 08/2011
2	Biological ProductsIBA 11/2012 - 10/2008
1	NucleosidesIBA 01/2022
1	pyrimidineIBA 01/2022
1	Adenine FDA LinkGeneric 01/2022
1	Analgesics (Analgesic Drugs)IBA 01/2022
1	DNA (Deoxyribonucleic Acid)IBA 01/2022
1	OligonucleotidesIBA 01/2022
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021
1	Dietary CalciumIBA 01/2017
1	SodiumIBA 01/2017
1	SymportersIBA 01/2017
1	GlobinsIBA 10/2016
1	Biomarkers (Surrogate Marker)IBA 12/2015
1	Peptides (Polypeptides)IBA 02/2015
1	Peptide Nucleic AcidsIBA 02/2015
1	Blood Glucose (Blood Sugar)IBA 06/2014
1	Metformin (Glucophage)FDA LinkGeneric 06/2014
1	diadenosine triphosphate (ApppA)IBA 11/2012
1	Adenosine Diphosphate (ADP)IBA 11/2012
1	alkylglycerophosphoethanolamine phosphodiesteraseIBA 08/2011
1	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 08/2011
1	FTY 720PIBA 08/2011
1	A-factor (Streptomyces)IBA 06/2010
1	AntibodiesIBA 10/2008
1	ParaffinIBA 10/2008
1	Conditioned Culture MediaIBA 10/2008
1	AntigensIBA 07/2008

Therapy/Procedure

5	Therapeutics 01/2021 - 08/2011
1	Enzyme Replacement Therapy 01/2022
1	Parathyroidectomy 01/2020
1	Intravenous Administration 10/2016